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Israeli and Hamas officials launched indirect talks Monday at an Egyptian resort on a U.S.-drafted peace plan to end the ruinous war in Gaza on the eve of its second anniversary.

Many uncertainties remain about the plan presented by U.S. President Donald Trump last week, including the disarmament of the militant group — a key Israeli demand — and the future governance of Gaza. Trump has indicated an agreement on Gaza could pave the way for a Middle East peace process that could reshape the region.

Despite Trump ordering Israel to stop the bombing, Israel continued to pound Gaza with airstrikes, killing at least 19 people in the last 24 hours, the territory’s Health Ministry said.

An Egyptian official said talks began at the Red Sea resort of Sharm el-Sheikh Monday afternoon. The official spoke on condition of anonymity because he was not authorized to speak publicly about the talks.

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Long-range Ukrainian drones and missiles hit a major Russian ammunition plant, a key oil terminal and an important weapons depot behind the front line, Ukraine's president and military said Monday, as Kyiv cranked up pressure on Moscow’s military logistics.

The Sverdlov ammunition plant in the Nizhny Novgorod region of western Russia was struck overnight, causing multiple explosions and a fire, the Ukrainian General Staff said. The plant supplies Russian forces with aviation and artillery ordnance, aviation bombs and anti-aircraft and anti-tank munitions, it said.

Ukraine also hit an oil terminal on the Russia-annexed Crimean Peninsula, starting a blaze, and an ammunition depot of Russia’s 18th Combined Arms Army, the General Staff said.

Russian authorities acknowledged a major Ukrainian drone attack over 14 regions, as well as Crimea and around the Black Sea and the Sea of Azov. But they gave few details beyond saying that air defenses shot down 251 Ukrainian drones — making it one of the biggest Ukrainian barrages of Russian territory since the war began on Feb. 24, 2022.

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A federal judge will not immediately block national guard troops from being deployed in Illinois after a lawsuit from the state against the president on Monday.

Troops from Texas could be deployed to Chicago on Tuesday or Wednesday, and Trump is also seeking to federalize the Illinois national guard. A similar effort to deploy troops to Portland was blocked by a judge in Oregon.

Illinois sued the Trump administration on behalf of the state and the city of Chicago on Monday after the president ordered national guard troops to deploy in the state against the governor’s wishes.

The Illinois attorney general, Kwame Raoul, filed a lawsuit seeking to stop Donald Trump from calling up the state’s national guard or sending in troops from other states “immediately and permanently”.

“The American people, regardless of where they reside, should not live under the threat of occupation by the United States military, particularly not simply because their city or state leadership has fallen out of a president’s favor,” the lawsuit says.

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Robert F. Kennedy Jr.’s making animal welfare a component of his Make America Healthy Again mission.

The health secretary has asked his agencies to refine high-tech methods of testing chemicals and drugs that don’t involve killing animals. He thinks phasing out animal testing and using the new methods will help figure out what’s causing chronic disease. It’s also got an ancillary benefit for Republicans: Animal-rights advocates like what they’re hearing.

That’s another opportunity for President Donald Trump to co-opt a traditionally left-leaning constituency.

“No one likes to see suffering,” Emily Trunnell, director of science advancement and outreach at People for the Ethical Treatment of Animals, told POLITICO. “The animal welfare benefits are very obvious to most people.”

Last week, the National Institutes of Health announced it would spend $87 million on a new center researching alternatives to animal testing and permit agency-supported researchers to use grant funding to find homes for retired lab animals.

Kennedy signed off because he thinks the new methods will enable scientists to more quickly and inexpensively draw conclusions about how chemicals and drugs work. He expects that’ll confirm his belief that chemicals in the environment and in food are making Americans sick and also speed cures for chronic diseases like cancer, heart disease and diabetes.

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A career federal prosecutor in Virginia has told colleagues she does not believe there is probable cause to file criminal mortgage fraud charges against New York attorney general Letitia James, according to a person familiar with the matter.

The prosecutor, Elizabeth Yusi, oversees major criminal cases in the Norfolk office for the US attorney for the eastern district of Virginia and plans to soon present her conclusion to Lindsey Halligan, a Trump ally, who was installed as the US attorney for the eastern district of Virginia last month. Yusi’s thinking was first reported by MSNBC on Monday.

The justice department declined to comment. The US attorney for the eastern district of Virginia did not return a request for comment.

The case sets up another high-profile confrontation between the justice department and Trump, who has fired attorneys who have refused to punish his enemies. Halligan, who has no prosecutorial experience, was put in the role at the urging of Trump after her predecessor concluded there wasn’t probable cause to file criminal charges against James Comey, the former FBI director. Halligan personally presented the case against Comey to a grand jury after she was appointed and secured a two-count indictment.

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Two years after the Hamas atrocities of 7 October 2023, in which militants killed about 1,200 Israelis, and amid the genocide in Gaza, in which Israel has killed more than 67,000 Palestinians, the need for peace has never been more urgent.

Palestinians are desperate for an end to starvation and airstrikes. Israelis want the war to end for the sake of remaining hostages and soldiers. Violence has reverberated across the region. Momentum has been growing around Donald Trump’s proposal, with both Benjamin Netanyahu and Hamas grudgingly indicating acceptance under US threat.

With indirect talks between Israel and Hamas beginning in in Egypt on Monday afternoon, there are frail hopes of progress at last. Yet both parties have made it clear that they reject major parts of the 20-point US plan, which begins with an immediate ceasefire, the return of all hostages – followed by the release of Palestinian prisoners – and the resumption of full aid.

For Netanyahu, perpetual war in Gaza and beyond extends his political survival. His far-right coalition partners want to expel Palestinians and settle Gaza. Hamas has no desire to sign itself out of existence, and handing back the last hostages would remove any leverage it retains. It has seen much of its leadership destroyed, as well as life in Gaza – but has also watched international public opinion shift unprecedentedly towards support for Palestinians, pulling governments in its wake. It can recruit from a huge pool of angry and traumatised young men.Egypt on Monday afternoon, there are frail hopes of progress at last. Yet both parties have made it clear that they reject major parts of the 20-point US plan, which begins with an immediate ceasefire, the return of all hostages – followed by the release of Palestinian prisoners – and the resumption of full aid.

For Netanyahu, perpetual war in Gaza and beyond extends his political survival. His far-right coalition partners want to expel Palestinians and settle Gaza. Hamas has no desire to sign itself out of existence, and handing back the last hostages would remove any leverage it retains. It has seen much of its leadership destroyed, as well as life in Gaza – but has also watched international public opinion shift unprecedentedly towards support for Palestinians, pulling governments in its wake. It can recruit from a huge pool of angry and traumatised young men.

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A federal judge on Saturday temporarily blocked President Trump’s deployment of 200 National Guard members to Portland, Ore. 

U.S. District Judge Karin Immergut granted Oregon and Portland officials’ request for a temporary restraining order, barring implementation of Defense Secretary Pete Hegseth’s memo that authorized federalizing the troops over the state’s objection.

“This is a nation of Constitutional law, not martial law,” the Trump-appointed judge wrote. 

Immergut denied the Trump administration’s request to pause her order while the administration appeals. Her order is set to expire in 14 days but could be extended, and she set a trial for Oct. 29.  

State and city officials jointly sued the Trump administration last month after the president vowed to protect “war-ravaged” Portland and its U.S. Immigration and Customs Enforcement (ICE) offices he described as “under siege.”

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scientists Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi from Japan won the 2025 Nobel Prize in Physiology or Medicine on Monday for their discoveries in controlling the immune system, creating openings for possible new autoimmune disease and cancer treatments.

This year's prize "relates to how we keep our immune system under control so we can fight all imaginable microbes and still avoid autoimmune disease," said Marie Wahren-Herlenius, a rheumatology professor at the Karolinska Institute.

Sakaguchi told reporters outside his university laboratory that "I feel it is a tremendous honour," Kyodo news agency reported.

The winners for medicine are selected by the Nobel Assembly of Sweden's Karolinska Institute medical university and receive a prize sum of 11 million Swedish crowns ($1.2 million), as well as a gold medal presented by Sweden's king.

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