A major winter storm is set to sweep the nation this weekend, bringing snow, sleet, ice and sub-zero wind chills from the southern Plains to the Northeast.
While it's still too early to predict snowfall totals for areas east of the Mississippi River, heavy snow is expected in Memphis, Nashville, Washington, Baltimore, Philadelphia and New York City.
Further west, 8 to 14 inches of snow are expected in Oklahoma City, 6 to 12 inches in Little Rock, Arkansas, and 5 to 10 inches in Amarillo, Texas.
Simultaneously, a long-duration extreme cold event is likely to move in during and after the storm. Those who lose power might endure several days of below-freezing temperatures.
In the Upper Midwest and Great Lakes region, wind chills of 40 to 50 below zero are possible. In Texas and along the Gulf Coast, temperatures could feel like they are in the single digits, down to 10 below zero.